DAO 96:61-68 (2011) - DOI: https://doi.org/10.3354/dao02383
First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report
F. A. Vigliano1,2,*, A. J. Marcaccini1, J. Sarradell3, R. Bermúdez4, M. I. Quiroga5
ABSTRACT: An external pinkish growing mass that emerged from the right nostril of an adult goldfish Carassius auratus L. was evaluated by means of light microscopy and immunohistochemistry. The neoplasm presented a well-developed fibrovascular stroma associated with solid cell nests and a large number of Flexner-Wintersteiner rosettes. Myelinated fibres were observed around them. Neoplastic cells showed a prominent degree of nuclear atypia and low mitotic activity. The latter was in agreement with the low reactivity of tumour cells to anti-proliferating cell nuclear antigen antibody. Immunohistochemistry also revealed anti-neuronal nitric oxide synthase, anti-S100 protein, anti-neuropeptide Y, and anti-cytokeratin immunoreactivity in tumour cells as well as in normal olfactory epithelium of goldfish control sections. Histopathological and immunohistochemical findings strongly suggest a diagnosis of an olfactory neuroblastoma (ONB). To our knowledge this is the first description of ONB in goldfish.
KEY WORDS: Tumour · Olfactory neuroblastoma · Goldfish · Carassius auratus · Histopathology · Immunohistochemistry
| Full text in pdf format | Cite this article as: Vigliano FA, Marcaccini AJ, Sarradell J, Bermúdez R, Quiroga MI
(2011) First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report. Dis Aquat Org 96:61-68. https://doi.org/10.3354/dao02383
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